BIOMETRY OF THE CORPUS CALLOSUM IN AN ADULT NIGERIAN POPULATION USING MAGNETIC RESONANCE

ABSTRACT

This was a prospective cross-sectional survey study conducted in the Radio diagnostic Department of National Hospital Abuja from June 2013 to January 2014 on 210 cases (111 males and 99 females). The specific objectives were to determine the: (i) biometric values of corpus callosum in an adult Nigerian population, (ii) differences in corpus callosal biometry among different sexes and (iii) relationship between age, body mass index and corpus callosal biometry.The following findings were made from the study: The mean corpus callosal biometry for the total population were: LC; 7.76±0.57cm, HC; 2.45±0.28cm, WG; 1.19±0.19cm, WS; 1.17±1.20cm, WC; 0.62±0.01cm, WCA; 0.58±0.01cm, WCP; 0.49±0.01cm, LR; 1.78±0.25cm. The mean corpus callosal biometry for the males were: LC; 7.82±0.45cm, HC; 2.46±0.29cm, WG; 1.20±0.19cm, WS; 1.17±1.21cm, WC; 0.62±0.10cm, WCA; 0.49±0.09cm, WCP; 0.49±0.07cm, LR; 1.78±0.25cm. The mean corpus callosal biometry for the females were: LC; 7.69±0.91cm, HC; 2.43±0.28cm, WG; 1.17±0.18cm, WS; 1.18±1.20cm, WC; 0.64±0.01cm, WCA; 0.59±0.08cm, WCP; 0.49±0.08cm, LR; 1.77±0.22cm. There was no significant difference (P >0.05) in the mean values of corpus callosal biometry in males when compared to the females. There was no significant relationship (P > 0.05) between corpus callosal biometry with age and BMI. The normal values from this work can give a clue in making diagnosis of some brain disease processes. Hence, the effect of brain diseases on the corpus callosum can further be researched upon among the Nigerian population.

 

TABLE OF CONTENT

Title page i

Certification ii

Dedication iii

Acknowledgement v

Table of content vi

List of tables viii

List of figures ix

Abstract x

CHAPTER ONE: INTRODUCTION

1.1Background of the Study 1

1.2Statement of the Problems 2

1.3Research Questions 2

1.4Hypothesis 3

1.5Objectives of The Study 3

1.6Specific Objectives 3

1.7Significance of the Study 3

1.8Scope of the Study 4

CHAPTER TWO: REVIEW OF RELATED LITERATURE

2.1Theoretical Review 5

2.1.1Anatomy of Corpus Callosum 5

2.1.2Basic Principle of MRI 7

2.1.3MR Brain Imaging 8

2.1.4Protocols adopted for Corpus Callosal Study 8

2.2Empirical Review 9

2.2.1Gender Related Studies 9

2.2.2Age Related Studies 11

2.2.3BMI Related Studies 11

2.2.4Brain Disorder Related Studies 12

2.2.5Mental Activities / Handedness Related Studies 13

CHAPTER THREE: METHODOLOGY

3.1Research Design 14

3.2Duration of Study 14

3.3Sources of Data 14

3.4Study Population 14

3.5Sampling Technique 14

3.6Sample Size 14

3.7Subject Selection 15

3.8Inclusion Criteria 15

3.9Exclusion Criteria 15

3.10Equipment Used 15

3.11Scanning Technique 15

3.12Ethical Considerations 16

3.13Informed Consent 16

3.14Method of Data Collection 16

3.15Measurements of Corpus Callosum 17

3.16Method of Data Analysis 18

CHAPTER FOUR: DATA ANALYSIS

4.1Normal Values of Corpus Callosal Biometry 19

4.2Descriptive Statistics of Age and BMI 20

4.3Comparing Males and Females Corpus Callosal Biometry 20

4.4Variations of Biometry with Age and BMI 21

4.5Correlation Analysis of Biometry with Age and BMI 33

CHAPTER FIVE: DISCUSSION / CONCLUSION

5.1Discussion 34

5.2Limitations of Study 35

5.3Conclusion 37

5.4Areas of Further Studies 38

REFERENCES 39

APPENDIX

Data Sheet 42

Ethical Clearance 50

Informed Concent 51

Measurements of Corpus Callosum in National Hospital Abuja 52